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EGF antibody (AA 956-985)

The Rabbit Polyclonal anti-EGF antibody has been validated for WB. It is suitable to detect EGF in samples from Human.
Catalog No. ABIN2793119

Quick Overview for EGF antibody (AA 956-985) (ABIN2793119)

Target

See all EGF Antibodies
EGF (Epidermal Growth Factor (EGF))

Reactivity

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Human

Host

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Rabbit

Clonality

  • 234
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Polyclonal

Conjugate

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This EGF antibody is un-conjugated

Application

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Western Blotting (WB)
  • Binding Specificity

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    AA 956-985

    Purpose

    Rabbit Anti-Human EGFR (Y978) Antibody

    Immunogen

    This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 956-985 amino acids from human EGFR.

    Isotype

    Ig Fraction
  • Application Notes

    Western Blot
    Recommended Dilutions
    WB: 1:1000Western blot analysis of EGFR (arrow) using rabbit polyclonal EGFR Antibody .

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.5 mg/mL

    Storage

    4 °C,-20 °C

    Storage Comment

    2-8°C (short-term), -20°C (long-term)
  • Target

    EGF (Epidermal Growth Factor (EGF))

    Alternative Name

    EGF

    Background

    Target Description: EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

    Gene Symbol: EGFR

    Molecular Weight

    134277 Da

    Gene ID

    1956

    UniProt

    P00533

    Pathways

    NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
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