TYROBP antibody (C-Term)
Quick Overview for TYROBP antibody (C-Term) (ABIN2793814)
Target
See all TYROBP AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 85-113, C-Term
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Purpose
- Rabbit Anti-Human TYROBP (C-term) Antibody
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Immunogen
- This TYROBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TYROBP.
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Isotype
- Ig Fraction
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Application Notes
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Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50Western blot analysis of TYROBP Antibody (C-term) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.500 mg/mL
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Storage
- 4 °C,-20 °C
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Storage Comment
- 2-8°C (short-term), -20°C (long-term)
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- TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
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Alternative Name
- TYROBP
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Background
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Target Description: TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.
Gene Symbol: TYROBP
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Molecular Weight
- 12179 Da
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Gene ID
- 7305
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UniProt
- O43914
Target
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