HAS2 antibody (Center)

Catalog No. ABIN2794747

Product Details anti-HAS2 Antibody

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Binding Specificity: AA 138-166, Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: Rabbit Anti-Human HAS2 (Center) Antibody

Immunogen: This HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the Central region of human HAS2.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50HAS2 Antibody (Center) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Alternative Name: HAS2 (HAS2 Products)

Synonyms: DG42 antibody, XHas2 antibody, Has2 antibody, hyaluronan synthase 2 antibody, hyaluronan synthase 2 S homeolog antibody, has2 antibody, HAS2 antibody, Has2 antibody, SHAS2 antibody, has2.S antibody

Background:

Target Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Gene Symbol: HAS2

Molecular Weight: 63566 Da

Gene ID: 3037

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process