KDELR1 antibody (C-Term)

Catalog No. ABIN2795626

This Rabbit Polyclonal antibody specifically detects KDELR1 in WB. It exhibits reactivity toward Human.

Quick Overview for KDELR1 antibody (C-Term) (ABIN2795626)

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDELR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KDELR1 Antibody

Binding Specificity: AA 185-211, C-Term

Purpose: Rabbit Anti-Human KDELR1 (C-term) Antibody

Immunogen: This KDELR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000KDELR1 Antibody (C-term) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.470 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for KDELR1

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Alternative Name: KDELR1

Background:

Target Description: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Gene Symbol: KDELR1

Molecular Weight: 24542 Da

Gene ID: 10945

UniProt: P24390

Pathways: Maintenance of Protein Location