KISS1 antibody (Center)

Catalog No. ABIN2796067

This Rabbit Polyclonal antibody specifically detects KISS1 in WB. It exhibits reactivity toward Human.

Quick Overview for KISS1 antibody (Center) (ABIN2796067)

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KISS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KISS1 Antibody

Binding Specificity: AA 235-263, Center

Purpose: Rabbit Anti-Human KISS1R (Center) Antibody

Immunogen: This KISS1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human KISS1R.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000KISS1R Antibody (Center) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.650 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for KISS1

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Alternative Name: KISS1

Background:

Target Description: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

Gene Symbol: KISS1R

Molecular Weight: 42586 Da

Gene ID: 84634

UniProt: Q969F8

Pathways: Positive Regulation of Peptide Hormone Secretion