WDR48 antibody (C-Term)

Catalog No. ABIN2797022

The Rabbit Polyclonal anti-WDR48 antibody has been validated for WB, IHC and FACS. It is suitable to detect WDR48 in samples from Human.

Quick Overview for WDR48 antibody (C-Term) (ABIN2797022)

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR48 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-WDR48 Antibody

Binding Specificity: AA 603-630, C-Term

Purpose: Rabbit Anti-Human WDR48 (C-term) Antibody

Immunogen: This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50WDR48 Antibody (C-term) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for WDR48

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Alternative Name: WDR48

Background:

Target Description: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

Gene Symbol: WDR48

Molecular Weight: 76210 Da

Gene ID: 57599

UniProt: Q8TAF3