HAT1 antibody (C-Term)

Catalog No. ABIN2797110

Product Details anti-HAT1 Antibody

Target: HAT1 (Histone Aminotransferase 1 (HAT1))

Binding Specificity: AA 389-419, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAT1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit Anti-Human KAT1 (HAT1) (C-term) Antibody

Immunogen: This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the C-terminal region of human KAT1 (HAT1).

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of hHAT1-E404 was detected using the purified Pab.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.0 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for HAT1

Target: HAT1 (Histone Aminotransferase 1 (HAT1))

Alternative Name: KAT1 (HAT1 Products)

Synonyms: GTK antibody, KAT1 antibody, KATI antibody, kynurenine aminotransferase 1 antibody, KYAT1 antibody

Background:

Target Description: Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.

Gene Symbol: HAT1

Molecular Weight: 49513 Da

Gene ID: 8520

UniProt: O14929