ADAM17 antibody (C-Term)

Catalog No. ABIN2798820

This anti-ADAM17 antibody is a Rabbit Polyclonal antibody detecting ADAM17 in WB. Suitable for Human.

Quick Overview for ADAM17 antibody (C-Term) (ABIN2798820)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM17 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADAM17 Antibody

Binding Specificity: AA 794-823, C-Term

Purpose: Rabbit Anti-Human ADAM17 (C-term) Antibody

Immunogen: This ADAM17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 794-823 amino acids from the C-terminal region of human ADAM17.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of ADAM17 Antibody (N-term) in Jurkat cell line lysates (35 μg/lane). ADAM17(arrow) was detected using the purified Pab.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: ADAM17

Background:

Target Description: ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, and also plays a prominent role in the activation of the Notch signaling pathway.

Gene Symbol: ADAM17

Molecular Weight: 93021 Da

Gene ID: 6868

UniProt: P78536

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus