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GCAP1 antibody (C-Term)

GUCA1A Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2798879
  • Target See all GCAP1 (GUCA1A) Antibodies
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Binding Specificity
    • 15
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    AA 160-191, C-Term
    Reactivity
    • 20
    • 18
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 34
    • 1
    Rabbit
    Clonality
    • 34
    • 1
    Polyclonal
    Conjugate
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GCAP1 antibody is un-conjugated
    Application
    • 29
    • 17
    • 13
    • 13
    • 9
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purpose
    Rabbit Anti-Human GCAP1 (C-term) Antibody
    Immunogen
    This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GUCA1A Primary Antibody
  • Application Notes
    Western Blot, Immunohistochemistry
    Recommended Dilutions
    WB: 1:1000, IHC: 1:50-100The anti-GCAP1 C-term Pab is used in Western blot to detect GCAP1 in Y79 cell lysate.
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. BC = breast carcinoma, HC = hepatocarcinoma.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2.0 mg/mL
    Storage
    4 °C,-20 °C
    Storage Comment
    2-8°C (short-term), -20°C (long-term)
  • Target
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Alternative Name
    GCAP1 (GUCA1A Products)
    Synonyms
    C6orf131 antibody, COD3 antibody, CORD14 antibody, GCAP antibody, GCAP1 antibody, GUCA antibody, GUCA1 antibody, dJ139D8.6 antibody, MGC84170 antibody, GUCA1A antibody, guca1a antibody, MGC146317 antibody, GC-A antibody, Gcap1 antibody, Guca1 antibody, mGCAP1 antibody, gcap1 antibody, guanylate cyclase activator 1A antibody, guanylate cyclase activator 1A L homeolog antibody, guanylate cyclase activator 1A (retina) antibody, guanylate cyclase activator 1a (retina) antibody, GUCA1A antibody, Guca1a antibody, guca1a.L antibody, guca1a antibody
    Background

    Target Description: Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.

    Gene Symbol: GUCA1A

    Molecular Weight
    22920 Da
    Gene ID
    2978
    UniProt
    P43080
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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