ITM2C antibody (AA 3-88) (AbBy Fluor® 594)

Catalog No. ABIN2803440

The Rabbit Polyclonal anti-ITM2C antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect ITM2C in samples from Human.

Quick Overview for ITM2C antibody (AA 3-88) (AbBy Fluor® 594) (ABIN2803440)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2C antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ITM2C Antibody (AbBy Fluor® 594)

Binding Specificity: AA 3-88

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ITM2C

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: ITM2C

Background:

Synonyms: BRI3, BRICD2C, BRICHOS domain containing 2C, Cerebral protein 14, CT-BRI3, E25, E25C , Integral membrane protein 2C, Integral membrane protein 3, Itm2c, ITM2C_HUMAN, ITM3 antibodyNPD018, Transmembrane protein BRI3.

Background: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Gene ID: 81618

UniProt: Q9NQX7