RND2 antibody (AA 1-80) (AbBy Fluor® 594)

Catalog No. ABIN2805983

This anti-RND2 antibody is a Rabbit Polyclonal antibody detecting RND2 in WB, IF (cc) and IF (p). Suitable for Mouse.

Quick Overview for RND2 antibody (AA 1-80) (AbBy Fluor® 594) (ABIN2805983)

Target: RND2 (rho Family GTPase 2 (RND2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RND2 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RND2 Antibody (AbBy Fluor® 594)

Binding Specificity: AA 1-80

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RND2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RND2

Target: RND2 (rho Family GTPase 2 (RND2))

Alternative Name: RND2/Rho7

Background:

Synonyms: ARHN, Rho 7, Rho family GTPase 2, Rho N, Rho related GTP-binding protein RhoN, Rho-related GTP-binding protein Rho7, Rho-related GTP-binding protein RhoN, Rho7, RhoN, Rnd 2, Rnd2, RND2_HUMAN.

Background: The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50 % amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30 % homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine, A, aliphatic amino acid, X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.

Pathways: Regulation of Cell Size