Dihydrofolate Reductase antibody (AbBy Fluor® 594)

Catalog No. ABIN2808570

This Rabbit Polyclonal antibody specifically detects Dihydrofolate Reductase in IF (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for Dihydrofolate Reductase antibody (AbBy Fluor® 594) (ABIN2808570)

Target: Dihydrofolate Reductase (DHFR)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dihydrofolate Reductase antibody is conjugated to AbBy Fluor® 594

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Dihydrofolate Reductase Antibody (AbBy Fluor® 594)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DHFR

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for Dihydrofolate Reductase

Target: Dihydrofolate Reductase (DHFR)

Alternative Name: DHFR

Background:

DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of DNA synthesis and cell death. Gene expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.

Synonyms: DHFR, DHFRP1, Dihydrofolate reductase, DYR, DYR_HUMAN, EC 1.5.1.3.

Gene ID: 1719

Pathways: Mitotic G1-G1/S Phases