DYNC1LI1 antibody (AA 451-523) (AbBy Fluor® 555)

Catalog No. ABIN2809231

The Rabbit Polyclonal anti-DYNC1LI1 antibody is suitable to detect DYNC1LI1 in samples from Human and Mouse. It has been validated for WB, IF (cc) and IF (p).

Quick Overview for DYNC1LI1 antibody (AA 451-523) (AbBy Fluor® 555) (ABIN2809231)

Target: DYNC1LI1 (Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC1LI1 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DYNC1LI1 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 451-523

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DNCLI1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DYNC1LI1

Target: DYNC1LI1 (Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1))

Alternative Name: DNCLI1

Background:

Synonyms: LIC1, DNCLI1, Cytoplasmic dynein 1 light intermediate chain 1, Dynein light chain A, DLC-A, Dynein light intermediate chain 1, cytosolic, DYNC1LI1

Background: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Gene ID: 51143

UniProt: Q9Y6G9