C5 antibody (AbBy Fluor® 594)

Catalog No. ABIN2810857

The Rabbit Polyclonal anti-C5 antibody has been validated for IF (p). It is suitable to detect C5 in samples from Human, Mouse and Rat.

Quick Overview for C5 antibody (AbBy Fluor® 594) (ABIN2810857)

Target: C5 (Complement Component 5 (C5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is conjugated to AbBy Fluor® 594

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-C5 Antibody (AbBy Fluor® 594)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: C5

Background:

The complement component proteins: C2, C3, C4 and C5 are potent anaphyl-atoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Activation of the complement system leads to the formation of C5b-9 terminal complex, and while C5b-9 can promote cell lysis, the sublytic assembly of C5b-9 on plasma membranes causes an opposite result and induces cell cycle activation and survival. C5b-9 can rescue oligodendrocytes from FAS-mediated apoptosis by regulating caspase-8 processing via PI 3-K signaling. C5b-9 may play a pro-inflammatory role in the acute phase of multiple sclerosis, but may also be neuroprotective during the chronic phase of the disease. Complement C5 precursor contains C5a anaphylatoxin. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis.

Synonyms: Anaphylatoxin C5a analog, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5, C5a, CO5_HUMAN, Complement C5 alpha'' chain, Complement C5, Complement component C5, CPAMD4.

Gene ID: 727

Pathways: Complement System, Carbohydrate Homeostasis