CNOT8 antibody (AbBy Fluor® 594)

Catalog No. ABIN2811779

This anti-CNOT8 antibody is a Rabbit Polyclonal antibody detecting CNOT8 in WB and IF (p). Suitable for Human, Mouse and Rat.

Quick Overview for CNOT8 antibody (AbBy Fluor® 594) (ABIN2811779)

Target: CNOT8 (CCR4-NOT Transcription Complex, Subunit 8 (CNOT8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT8 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CNOT8 Antibody (AbBy Fluor® 594)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CNOT8

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CNOT8

Target: CNOT8 (CCR4-NOT Transcription Complex, Subunit 8 (CNOT8))

Alternative Name: CNOT8

Background:

Synonyms: CAF 1, CAF 2, CAF1, CAF1 like protein, CAF1-like protein, CAF2, CAL, CALp, CCR4 associated factor 8, CCR4 NOT transcription complex subunit 8, CCR4-associated factor 8, CCR4-NOT transcription complex subunit 8, CNOT 8, Cnot8, CNOT8_HUMAN, hCAF1, PGK promoter directed over production, POP 2, POP2.

Background: The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits within the complex are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT8 (CCR4-NOT transcription complex subunit 8), also known as CALIF or POP2, is a 292 amino acid protein that localizes to both the nucleus and the cytoplasm and functions as part of the CCR-NOT complex. Expressed ubiquitously, CNOT8 plays a role in transcriptional regulation for a diverse set of processes.

Gene ID: 9337