F12 antibody (Light Chain) (AbBy Fluor® 594)

Catalog No. ABIN2813028

This Rabbit Polyclonal antibody specifically detects F12 in WB and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for F12 antibody (Light Chain) (AbBy Fluor® 594) (ABIN2813028)

Target: F12 (Coagulation Factor XII (F12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This F12 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-F12 Antibody (AbBy Fluor® 594)

Binding Specificity: Light Chain

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Coagulation factor XIIa light chain

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for F12

Target: F12 (Coagulation Factor XII (F12))

Alternative Name: Factor XII

Background:

Synonyms: Factor XII, Coagulation factor XIIa light chain, Factor XII, Coagulation factor XII, Factor XII light chain, F12, F12 deficiency, FA12_HUMAN, Factor XII deficiency, HAE3, HAEX, HAF, HAF deficiency, Hageman factor, Beta-factor XIIa part 2.

Background: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].

Gene ID: 2161

Pathways: Complement System