HDAC11 antibody (C-Term)

Catalog No. ABIN2844703

There are 2+ publications for this product available. The Rabbit Polyclonal anti-HDAC11 antibody is suitable to detect HDAC11 in samples from Human and Mouse. It has been validated for WB and IHC (p).

Quick Overview for HDAC11 antibody (C-Term) (ABIN2844703)

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2589

Product Details anti-HDAC11 Antibody

Binding Specificity: AA 313-345, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-HDAC11 antibody (ABIN2844703)

Joshi, Greco, Guise, Luo, Yu, Nesvizhskii, Cristea: "The functional interactome landscape of the human histone deacetylase family." in: Molecular systems biology, Vol. 9, pp. 672, (2013) (PubMed).

Keedy, Archin, Gates, Espeseth, Hazuda, Margolis: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).

Target Details for HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Alternative Name: HDAC11

Background: HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Molecular Weight: 39183

Gene ID: 79885

NCBI Accession: NP_001129513, NP_079103

UniProt: Q96DB2