Mre11 antibody

Catalog No. ABIN363310

This Rabbit Polyclonal antibody specifically detects Mre11 in WB, IHC, IP, IF, ICC, FACS and ChIP. It exhibits reactivity toward Human, Rat, Mouse, Chicken and Hamster.

Quick Overview for Mre11 antibody (ABIN363310)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivity: Human, Rat, Mouse, Chicken, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Chromatin Immunoprecipitation (ChIP)

Product Details anti-Mre11 Antibody

Specificity: Reacts with Mre11 from human, mouse, rat, chicken, hamster

Purification: Antiserum

Immunogen: Full length human Mre11 protein.

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IF : 1/200 - IP : 3 μL - WB : 1/5000 - IHC: 1/10 to 1/200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: , Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Background: The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions.This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity.

UniProt: P49959

Pathways: DNA Damage Repair