GPR77 antibody (Internal Region)

Catalog No. ABIN2854275

Product Details anti-GPR77 Antibody

Target: GPR77 (G Protein-Coupled Receptor 77 (GPR77))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR77 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Cow (Bovine)

Cross-Reactivity (Details): Bovine (83 %)

Characteristics: Rabbit polyclonal antibody to C5L2(GPR77) (G protein-coupled receptor 77)
C5L2(GPR77) antibody [N3C1], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human C5L2(GPR77). The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Immunohistochemistry Assay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections) Assay-dependent dilution Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceImmunohistochemistryAssay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections)Assay-dependent dilution

Comment:

Positive Control: Synthetic peptide: 1:8,000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS, 50 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for GPR77

Target: GPR77 (G Protein-Coupled Receptor 77 (GPR77))

Alternative Name: C5L2(GPR77) (GPR77 Products)

Synonyms: GPR77 antibody, C5L2 antibody, GPF77 antibody, E030029A11Rik antibody, Gpr77 antibody, complement component 5a receptor 2 antibody, C5AR2 antibody, C5ar2 antibody

Background: The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1, MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM]

Cellular Localization: Cell membrane

Molecular Weight: 36 kDa

Gene ID: 27202