TTR antibody

Catalog No. ABIN2854289

The Rabbit Polyclonal anti-TTR antibody is suitable to detect TTR in samples from Human. It has been validated for WB.

Quick Overview for TTR antibody (ABIN2854289)

Target: TTR (Transthyretin (TTR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TTR Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit Polyclonal antibody to Transthyretin (transthyretin)
Transthyretin antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Full length human Prealbumin Recombinant protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: rat plasma

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.58 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: transthyretin

Background: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein, it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Cellular Localization: Secreted , Cytoplasm

Molecular Weight: 16 kDa

Gene ID: 7276

UniProt: P02766

Pathways: Hormone Transport