ODC1 antibody

Catalog No. ABIN2854335

Product Details anti-ODC1 Antibody

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ODC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit polyclonal antibody to ODC (ornithine decarboxylase 1)
ODC antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human ODC. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HepG2

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.19 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-ODC1 antibody (ABIN2854335)

Sekiguchi, Seki, Kawai, Yoshida, Yoshida, Isobe, Hoshino, Shirai, Tanaka, Souzaki, Watanabe, Arakawa, Nannya, Suzuki, Fujii, Kataoka, Shiraishi, Chiba, Tanaka, Shimamura, Sato, Sato-Otsubo, Kimura et al.: "Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets. ..." in: NPJ precision oncology, Vol. 4, pp. 20, (2020) (PubMed).

Target Details for ODC1

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Alternative Name: ornithine decarboxylase 1 (ODC1 Products)

Synonyms: CG8721 antibody, Dmel\\CG8721 antibody, dodc1 antibody, odc antibody, fc54f04 antibody, fi06d08 antibody, CHUNP6922 antibody, wu:fc54f04 antibody, wu:fi06d08 antibody, odc2 antibody, xODC1 antibody, xodc2 antibody, DDBDRAFT_0204020 antibody, DDBDRAFT_0237755 antibody, DDB_0204020 antibody, DDB_0237755 antibody, ODC antibody, odc1 antibody, ODC1 antibody, Odc antibody, odc1-a antibody, Ornithine decarboxylase 1 antibody, ornithine decarboxylase 1 antibody, ornithine decarboxylase antibody, diaminopimelate decarboxylase antibody, Orn/DAP/Arg decarboxylase 2 domain-containing protein antibody, Diaminopimelate decarboxylase antibody, Ornithine decarboxylase antibody, ornithine decarboxylase 1 L homeolog antibody, ornithine decarboxylase, structural 1 antibody, Odc1 antibody, odc1 antibody, ODC1 antibody, odc antibody, RR_RS04895 antibody, ASA_RS06380 antibody, LOC100232922 antibody, odc1.L antibody, odc-1 antibody

Background: This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.

Molecular Weight: 51 kDa

Gene ID: 4953

UniProt: P11926