PTK7 antibody (C-Term)

Catalog No. ABIN2854472

The Rabbit Polyclonal anti-PTK7 antibody has been validated for FACS. It is suitable to detect PTK7 in samples from Human. There is 1 publication available.

Quick Overview for PTK7 antibody (C-Term) (ABIN2854472)

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTK7 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-PTK7 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to CCK4 (CCK4 protein tyrosine kinase 7)
CCK4 antibody [C1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human CCK4. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.36 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-PTK7 antibody (ABIN2854472)

Chen, Khatri, Mazur, Polin, Zheng, Vaka, Hoang, Shrager, Xu, Vicent, Butte, Sweet-Cordero: "A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma." in: Cancer research, Vol. 74, Issue 10, pp. 2892-902, (2014) (PubMed).

Target Details for PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Alternative Name: protein tyrosine kinase 7 (inactive)

Background: Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.

Cellular Localization: Membrane, Single-pass type I membrane protein

Molecular Weight: 118 kDa

Gene ID: 5754

UniProt: Q13308

Pathways: RTK Signaling, Tube Formation