ATF6 antibody (C-Term)

Catalog No. ABIN2854487

The Rabbit Polyclonal anti-ATF6 antibody has been validated for WB. It is suitable to detect ATF6 in samples from Human. There is 1 publication available.

Quick Overview for ATF6 antibody (C-Term) (ABIN2854487)

Target: ATF6 (Activating Transcription Factor 6 (ATF6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF6 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: KO Validated

Product Details anti-ATF6 Antibody

Binding Specificity: C-Term

Specificity: This antibody was raised against the C-terminus of human ATF6 alpha, meaning it can only detect the uncleaved form.,Knockdown/Knockout validation was supported by references (PMID:29535165)

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit polyclonal antibody to ATF6 (activating transcription factor 6)
ATF6 antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ATF6. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Validatio: KO/KD, Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-ATF6 antibody (ABIN2854487)

Wang, Lai, Yang, Lin, Chen, Tsai: "Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol." in: Antioxidants (Basel, Switzerland), Vol. 9, Issue 8, (2020) (PubMed).

Target Details for ATF6

Target: ATF6 (Activating Transcription Factor 6 (ATF6))

Alternative Name: activating transcription factor 6

Background: ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM]

Cellular Localization: Endoplasmic reticulum membrane , Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus

Molecular Weight: 75 kDa

Gene ID: 22926

UniProt: P18850

Pathways: ER-Nucleus Signaling, Unfolded Protein Response