Reactivity: Chemical
Host: Rabbit
Polyclonal
unconjugated
Restrictions
For Research Use only
Format
Liquid
Concentration
Lot specific
Buffer
Neat Serum
Handling Advice
Avoid repeated freeze/thaw cycles
Storage
-20 °C
Storage Comment
Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
Target
Digitoxin
Target Type
Chemical
Background
Digitoxin is a purified cardiac glycoside similar in structure and function to Digoxin. Unlike Digoxin, Digitoxin is eliminated from the body via the liver and not the kidneys. Both drugs are used to treat various heart conditions. Cardiac glycosides bind to a site on the extracellular aspect of the a-subunit of the Na+/K+ ATPase pump in the membranes of heart cells (myocytes). This causes an increase in the level of sodium ions in the myocytes, which then leads to a rise in the level of calcium ions.