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PAX8 antibody

KO Validated PAX8 Reactivity: Human WB, IHC, IF, IHC (p), IP, ICC, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855097
  • Target See all PAX8 Antibodies
    PAX8 (Paired Box 8 (PAX8))
    Reactivity
    • 111
    • 48
    • 45
    • 20
    • 20
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Human
    Host
    • 72
    • 38
    • 1
    Rabbit
    Clonality
    • 56
    • 55
    Polyclonal
    Conjugate
    • 62
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAX8 antibody is un-conjugated
    Application
    • 87
    • 36
    • 31
    • 30
    • 25
    • 16
    • 15
    • 12
    • 11
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)
    Cross-Reactivity
    Dog, Human, Mouse, Rat
    Characteristics
    Rabbit Polyclonal antibody to PAX8 (paired box 8)
    PAX8 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Grade
    KO Validated
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human PAX8. The exact sequence is proprietary.
    Isotype
    IgG
  • Application Notes
    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: 293T nuclear extract , DDDDK-tagged PAX8-transfected 293T

    Validation: KO/KD, Orthogonal, Overexpression

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.87 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Shi, Yin, Cai, Yan, Jia, Ma, Zhang, Zhang, Gu, Zhang, Di, Zhuang: "PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors." in: eLife, Vol. 8, (2020) (PubMed).

    Sun, Lu, Wu, Ouyang, Xing, Hou, Shi, Wu: "PTEN-knockdown disrupts the morphology, growth pattern and function of Nthy-Ori 3-1 cells by downregulating PAX8 expression." in: Oncology letters, Vol. 18, Issue 6, pp. 6732-6740, (2019) (PubMed).

  • Target
    PAX8 (Paired Box 8 (PAX8))
    Alternative Name
    paired box 8 (PAX8 Products)
    Synonyms
    PAX8 antibody, XPax-8 antibody, XPax8 antibody, pax-8 antibody, PAX-8 antibody, Pax-8 antibody, paired box 8 antibody, paired box 8 L homeolog antibody, PAX8 antibody, pax8 antibody, Pax8 antibody, pax8.L antibody
    Background
    This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternateively spliced transcript variants encoding different isoforms have been described.

    Cellular Localization: Nucleus
    Molecular Weight
    48 kDa
    Gene ID
    7849
    UniProt
    Q06710
    Pathways
    Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
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