ARHGDIB antibody

Catalog No. ABIN2855594

The Rabbit Polyclonal anti-ARHGDIB antibody has been validated for WB. It is suitable to detect ARHGDIB in samples from Human.

Quick Overview for ARHGDIB antibody (ABIN2855594)

Target: ARHGDIB (rho GDP Dissociation Inhibitor (GDI) beta (ARHGDIB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGDIB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ARHGDIB Antibody

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit polyclonal antibody to Rho GDI2 (Rho GDP dissociation inhibitor (GDI) beta)
Rho GDI2 antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Rho GDI2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T , A431 , H1299 , HeLaS3 , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for ARHGDIB

Target: ARHGDIB (rho GDP Dissociation Inhibitor (GDI) beta (ARHGDIB))

Alternative Name: Rho GDP dissociation inhibitor beta

Background: Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM]

Cellular Localization: Cytoplasm

Molecular Weight: 23 kDa

Gene ID: 397

UniProt: P52566

Pathways: Caspase Cascade in Apoptosis