FGFRL1 antibody

Catalog No. ABIN2855700

This anti-FGFRL1 antibody is a Rabbit Polyclonal antibody detecting FGFRL1 in WB and IHC (p). Suitable for Human.

Quick Overview for FGFRL1 antibody (ABIN2855700)

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFRL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FGFRL1 Antibody

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to FGFR-5 (fibroblast growth factor receptor-like 1)
FGFR-5 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human FGFR5. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: FGFRL1-transfected 293T , HepG2 membrane extract

Validation: Orthogonal, Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.42 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for FGFRL1

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Alternative Name: fibroblast growth factor receptor like 1

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Cellular Localization: Membrane, Single-pass type I membrane protein

Molecular Weight: 55 kDa

Gene ID: 53834

UniProt: Q8N441

Pathways: RTK Signaling