MMP7 antibody (C-Term)

Catalog No. ABIN2855888

Product Details anti-MMP7 Antibody

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Cow, Human, Mouse, Rat

Characteristics: Rabbit polyclonal antibody to MMP7 (matrix metallopeptidase 7 (matrilysin, uterine))
MMP7 antibody [C2C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MMP7. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.45 mg/mL

Buffer: 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-MMP7 antibody (ABIN2855888)

Cai, Sun, Duan, Qiu, Dai, Yang, He: "FHL2 promotes tubular epithelial-to-mesenchymal transition through modulating β-catenin signalling." in: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1684-1695, (2019) (PubMed).

Luo, Liao, Liao, Chen, Huang, Fan, Liao: "The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma." in: World journal of surgical oncology, Vol. 16, Issue 1, pp. 36, (2018) (PubMed).

Oelusarz, Nichols, Grunz-Borgmann, Chen, Akintola, Catania, Burghardt, Trzeciakowski, Parrish: "Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney." in: Physiological reports, Vol. 1, Issue 5, (2013) (PubMed).

Target Details for MMP7

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Alternative Name: matrix metallopeptidase 7 (MMP7 Products)

Synonyms: MAT antibody, MPMM antibody, MMP-7 antibody, MPSL1 antibody, PUMP-1 antibody, matrilysin antibody, LOC727698 antibody, MMP7 antibody, Matrilysin antibody, matrix metallopeptidase 7 antibody, MMP7 antibody, Mmp7 antibody

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molecular Weight: 30 kDa

Gene ID: 4316

UniProt: P09237

Pathways: Production of Molecular Mediator of Immune Response