SERPING1 antibody (Center)

Catalog No. ABIN2856082

Product Details anti-SERPING1 Antibody

Target: SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))

Binding Specificity: Center

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPING1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Characteristics: Rabbit Polyclonal antibody to C1 inhibitor (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1)
C1 inhibitor antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human C1 inhibitor. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Immunohistochemistry Assay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceImmunohistochemistryAssay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Comment:

Positive Control: 293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-SERPING1 antibody (ABIN2856082)

Kwon, Kim, Hwang, Kim, Kim, Kim, Lee, Im, Lee, Hwang: "Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes." in: Transgenic research, Vol. 26, Issue 1, pp. 153-163, (2018) (PubMed).

Hayashi, Ushizawa, Hosoe, Takahashi: "Differential gene expression of serine protease inhibitors in bovine ovarian follicle: possible involvement in follicular growth and atresia." in: Reproductive biology and endocrinology : RB&E, Vol. 9, pp. 72, (2011) (PubMed).

Target Details for SERPING1

Target: SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))

Alternative Name: C1 Inhibitor (SERPING1 Products)

Synonyms: fb64f02 antibody, im:7159527 antibody, si:dkeyp-110g5.2 antibody, wu:fb60c09 antibody, wu:fb62a08 antibody, wu:fb64f02 antibody, LOC100136072 antibody, C1-INH antibody, C1INH antibody, C1nh antibody, C1IN antibody, C1NH antibody, HAE1 antibody, HAE2 antibody, serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody, C1 inhibitor antibody, serpin family G member 1 antibody, serine (or cysteine) peptidase inhibitor, clade G, member 1 antibody, serping1 antibody, LOC100136072 antibody, SERPING1 antibody, Serping1 antibody

Background: This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.

Cellular Localization: Secreted

Molecular Weight: 55 kDa

Gene ID: 710

Pathways: Complement System