SERPING1 antibody (Center)

Catalog No. ABIN2856082

This Rabbit Polyclonal antibody specifically detects SERPING1 in WB, IHC and IHC (p). It exhibits reactivity toward Human and Cow. It has been mentioned in 2+ publications

Quick Overview for SERPING1 antibody (Center) (ABIN2856082)

Target: SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPING1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SERPING1 Antibody

Binding Specificity: Center

Characteristics: Rabbit Polyclonal antibody to C1 inhibitor (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1)
C1 inhibitor antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human C1 inhibitor. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Immunohistochemistry Assay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceImmunohistochemistryAssay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Comment:

Positive Control: 293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-SERPING1 antibody (ABIN2856082)

Kwon, Kim, Hwang, Kim, Kim, Kim, Lee, Im, Lee, Hwang: "Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes." in: Transgenic research, Vol. 26, Issue 1, pp. 153-163, (2018) (PubMed).

Hayashi, Ushizawa, Hosoe, Takahashi: "Differential gene expression of serine protease inhibitors in bovine ovarian follicle: possible involvement in follicular growth and atresia." in: Reproductive biology and endocrinology : RB&E, Vol. 9, pp. 72, (2011) (PubMed).

Target Details for SERPING1

Target: SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))

Alternative Name: C1 Inhibitor

Background: This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.

Cellular Localization: Secreted

Molecular Weight: 55 kDa

Gene ID: 710

Pathways: Complement System