LHCGR antibody (C-Term)

Catalog No. ABIN2857013

There are 2+ publications for this product available. The Rabbit Polyclonal anti-LHCGR antibody is suitable to detect LHCGR in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for LHCGR antibody (C-Term) (ABIN2857013)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LHCGR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LHCGR Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to LHR (luteinizing hormone/choriogonadotropin receptor)
LHR antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human LHR. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: H1299

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-LHCGR antibody (ABIN2857013)

Liu, Hsu, Chen, Chiu, Lin: "A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo." in: Scientific reports, Vol. 9, Issue 1, pp. 11143, (2019) (PubMed).

Wu, Wang, Chueh, Yang, Huang, Lin, Wang, Connolly, Hu, Gomez-Sanchez, Peng, Wu: "The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes." in: Scientific reports, Vol. 7, pp. 39121, (2018) (PubMed).

Target Details for LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Alternative Name: luteinizing hormone/choriogonadotropin receptor

Background: This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.

Cellular Localization: Cell membrane, Multi-pass membrane protein

Molecular Weight: 79 kDa

Gene ID: 3973

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling