8-OHDG antibody

Catalog No. ABIN285804

Cited in 2+ publications. The Goat Polyclonal anti-8-OHDG antibody (ABIN285804) specifically detects 8-OHDG in ELISA and IHC.

Quick Overview for 8-OHDG antibody (ABIN285804)

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Host: Goat

Clonality: Polyclonal

Conjugate: This 8-OHDG antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-8-OHDG Antibody

Immunogen: 8-Hydroxyguanosine antibody was raised in goat using 8-Hydroxyguansoine as the immunogen.

Application Details

Application Notes: ELISA: >1:250,000, IHC-P: >1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as liquid whole serum without preservative

Preservative: Without preservative

Handling Advice: Avoid repeated freeze/thaw cycles

Storage: -20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

References for anti-8-OHDG antibody (ABIN285804)

Tuerdi, Kikuta, Kinoshita, Kamogashira, Kondo, Yamasoba: "Zone-specific damage of the olfactory epithelium under protein restriction." in: Scientific reports, Vol. 10, Issue 1, pp. 22175, (2021) (PubMed).

Jeannot, Pogribny, Beland, Rusyn: "Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells." in: Cancer letters, Vol. 301, Issue 2, pp. 161-7, (2011) (PubMed).

Target Details for 8-OHDG

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Target Type: Chemical

Background: 8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually leads to several diseases in humans, such as arteriosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer?s disease.