RAGE antibody

Catalog No. ABIN285943

This Goat Polyclonal antibody specifically detects RAGE in WB, IHC and ELISA. It exhibits reactivity toward Mammalian.

Quick Overview for RAGE antibody (ABIN285943)

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivity: Mammalian

Host: Goat

Clonality: Polyclonal

Conjugate: This RAGE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-RAGE Antibody

Specificity: Specific for Amino acid sequence 385-399 of human receptor for advanced glycated end products.0.1% NaN3

Immunogen: RAGE antibody was raised in goat using a peptide, PKKPPQRLEWKLNTGRTE, as the immunogen.

Application Details

Application Notes: ELISA: >1:260,676, IHC-P: >1:400, WB: >1:3,000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as liquid whole serum without preservative

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details for RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Alternative Name: RAGE

Background: The Receptor for Advanced Glycosylated End Products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins