DRD3 antibody

Catalog No. ABIN289418

The Rabbit Polyclonal anti-DRD3 antibody is suitable to detect DRD3 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for DRD3 antibody (ABIN289418)

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DRD3 Antibody

Cross-Reactivity (Details): This human D3R peptide showed no significant sequence homology with other dopamine receptors (D1, D2, D4 or D5). It is 94 % conserved in monkey, 72 % with mouse and 68 % with rat D3R receptors.

Purification: Affinity chromatography purified

Immunogen: Dopamine D3 receptor antibody was raised in rabbit using a 19 amino acid peptide of human D3 R as the immunogen.

Isotype: IgG

Application Details

Application Notes: ELISA: 0.5-1 µg/mL, WB: 1-10 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Affinity purified IgG lyophilized from PBS, with 0.1 % BSA, and 0.05 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details for DRD3

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Alternative Name: Dopamine D3 Receptor

Background: Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. D3 is encoded by the Dopamine receptor D3 gene (DRD3). Maximum expression of dopamine D3 receptors is noted in the islands of Calleja and nucleus accumbens.

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity