Mannose Receptor antibody

Catalog No. ABIN291690

This anti-Mannose Receptor antibody is a Mouse Monoclonal antibody detecting Mannose Receptor in IHC and IHC (fro). Suitable for Human.

Quick Overview for Mannose Receptor antibody (ABIN291690)

Target: Mannose Receptor (MR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mannose Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 7-450

Product Details anti-Mannose Receptor Antibody

Specificity: Specific for human CD206, otherwise known as macrophage mannose receptor (MMR), a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens. CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites.

Purification: Affinity purified

Immunogen: Monocyte-derived dendritic cells.

Type of Immunogen: Cells

Isotype: IgG2a

Application Details

Application Notes: Approved: IHC, IHC-Fr (1:50 - 1:500)

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Short term: -20°C
Long term: -20°C.

Target Details for Mannose Receptor

Target: Mannose Receptor (MR)

Alternative Name: Mannose Receptor / CD206

Background: Name/Gene ID: MRC1

Synonyms: MRC1, BA541I19.1, CLEC13D, CD206, CD206 antigen, Macrophage mannose receptor 1, Mannose Receptor, Macrophage mannose receptor, MMR, Mannose receptor, C type 1, MRC1L1, CLEC13DL

Gene ID: 4360