MALT1 antibody (AA 43-57)

Catalog No. ABIN298719

The Rabbit Polyclonal anti-MALT1 antibody (ABIN298719) specifically detects MALT1 in WB, IHC and IHC (p). The antibody is reactive with Human samples.

Quick Overview for MALT1 antibody (AA 43-57) (ABIN298719)

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MALT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MALT1 Antibody

Binding Specificity: AA 43-57

Specificity: A synthetic peptide corresponding to amino acids 43-57 (ELLDQAPEGRGWRRL) of human MALT1 (GenBank No. NP_776216.1) was used as immunogen. The immunogen sequence is 100 % conserved between Malt1 isoforms a and b.

Predicted Reactivity: Percent identity by BLAST analysis: Human (100%) Monkey (93%) Gorilla, Gibbon, Elephant (87%) Marmoset, Bovine, Bat (80%).

Purification: Protein G purified

Immunogen: A synthetic peptide corresponding to amino acids 43-57 (ELLDQAPEGRGWRRL) of human MALT1 (GenBank No. NP_776216.1). The immunogen sequence is 100% conserved between Malt1 isoforms a and b. Percent identity by BLAST analysis: Human (100%), Monkey (93%), Chimpanzee, Gorilla, Orangutan, Gibbon, Elephant (87%), Galago, Marmoset, Bovine, Cat (80%), Mouse, Rat (73%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: IHC, IHC-P (10 μg/mL), WB (0.5 - 2 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 10 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Target Details for MALT1

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Alternative Name: MALT1

Background: Name/Gene ID: MALT1
Subfamily: Cysteine C14
Family: Protease

Synonyms: MALT1, Caspase-like protein, MLT, MLT1, Paracaspase, MALT associated translocation

Gene ID: 10892

NCBI Accession: NP_776216

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins