IKZF1 antibody (AA 1-270)

Catalog No. ABIN3015622

This anti-IKZF1 antibody is a Rabbit Polyclonal antibody detecting IKZF1 in WB, IF and ChIP. Suitable for Human.

Quick Overview for IKZF1 antibody (AA 1-270) (ABIN3015622)

Target: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKZF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)

Product Details anti-IKZF1 Antibody

Binding Specificity: AA 1-270

Sequence: MDADEGQDMS QVSGKESPPV SDTPDEGDEP MPIPEDLSTT SGGQQSSKSD RVVASNVKVE TQSDEENGRA CEMNGEECAE DLRMLDASGE KMNGSHRDQG SSALSGVGGI RLPNGKLKCD ICGIICIGPN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHSGE KPFKCHLCNY ACRRRDALTG HLRTHSVIKE ETNHSEMAED LCKIGSERSL VLDRLASNVA KRKSSMPQKF LGDKGLSDTP YDSSASYEKE NEMMKSHVMD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human Ikaros (NP_001207694.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200,ChIP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IKZF1

Target: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Alternative Name: IKZF1

Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).,IKZF1,CVID13,Hs.54452,IK1,IKAROS,LYF1,LyF-1,PPP1R92,PRO0758,ZNFN1A1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,IKZF1

Molecular Weight: 24-31 kDa/41-57 kDa

Gene ID: 10320

UniProt: Q13422

Pathways: Production of Molecular Mediator of Immune Response