Cofilin antibody (pSer3)

Catalog No. ABIN3019729

There is 1 publication for this product available. The Rabbit Polyclonal anti-Cofilin antibody is suitable to detect Cofilin in samples from Human. It has been validated for WB, IHC and IF.

Quick Overview for Cofilin antibody (pSer3) (ABIN3019729)

Target: Cofilin (CFL1) (Cofilin 1 (CFL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cofilin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Cofilin Antibody

Binding Specificity: pSer3

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding S3 of human CFL1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:100 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Cofilin antibody (ABIN3019729)

Hu, Guo, Feng, Zhang, Zhou, Ma, Shen, Tong, Yan, Zhu, Bian, Lai, Deng, Ding: "MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis." in: Oncotarget, Vol. 6, Issue 26, pp. 22410-23, (2016) (PubMed).

Target Details for Cofilin

Target: Cofilin (CFL1) (Cofilin 1 (CFL1))

Alternative Name: CFL1

Background: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH -dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH -dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],CFL1,CFL,HEL-S-15,cofilin,cofilin-1,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cell Adhesion,Cytoskeleton,Microfilaments,Microtubules,Actins,TGF-b-Smad Signaling Pathway,Immunology & Inflammation,Neuroscience,Cell Type Marker,Cardiovascular,Heart,Contractility,Neuron marker,Axon marker,Protein phosphorylation,CFL1

Molecular Weight: 18 kDa

Gene ID: 1072

UniProt: P23528

Pathways: Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus, CXCR4-mediated Signaling Events