PDGFB antibody (AA 20-241)

Catalog No. ABIN3021689

This anti-PDGFB antibody is a Rabbit Polyclonal antibody detecting PDGFB in WB, IHC and IF. Suitable for Human.

Quick Overview for PDGFB antibody (AA 20-241) (ABIN3021689)

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PDGFB Antibody

Binding Specificity: AA 20-241

Sequence: AEGDPIPEEL YEMLSDHSIR SFDDLQRLLH GDPGEEDGAE LDLNMTRSHS GGELESLARG RRSLGSLTIA EPAMIAECKT RTEVFEISRR LIDRTNANFL VWPPCVEVQR CSGCCNNRNV QCRPTQVQLR PVQVRKIEIV RKKPIFKKAT VTLEDHLACK CETVAAARPV TRSPGGSQEQ RAKTPQTRVT IRTVRVRRPP KGKHRKFKHT HDKTALKETL GA

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-241 of human PDGFB (NP_002599.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Alternative Name: PDGFB

Background: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.,PDGFB,IBGC5,PDGF-2,PDGF2,SIS,SSV,c-sis,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Immunology & Inflammation,Cytokines,Cardiovascular,Angiogenesis,Blood,Serum Proteins,Hypoxia,Heart,Cardiovascular diseases,Heart disease,PDGFB

Molecular Weight: 25 kDa/27 kDa

Gene ID: 5155

UniProt: P01127

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling