UCP3 antibody (AA 1-110)

Catalog No. ABIN3022086

This Rabbit Polyclonal antibody specifically detects UCP3 in WB. It exhibits reactivity toward Human.

Quick Overview for UCP3 antibody (AA 1-110) (ABIN3022086)

Target: UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UCP3 Antibody

Binding Specificity: AA 1-110

Sequence: MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human UCP3 (NP_073714.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UCP3

Target: UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Alternative Name: UCP3

Background: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression, this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.,UCP3,SLC25A9,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Endocrine and metabolic diseases,Diabetes,Obesity,Neuroscience,Cardiovascular,Hypoxia,Lipids,Fatty Acids,UCP3

Molecular Weight: 22 kDa/29 kDa/34 kDa

Gene ID: 7352

UniProt: P55916

Pathways: Proton Transport