Cyclin T1 antibody (AA 220-320)

Catalog No. ABIN3022810

This Rabbit Polyclonal antibody specifically detects Cyclin T1 in WB. It exhibits reactivity toward Human.

Quick Overview for Cyclin T1 antibody (AA 220-320) (ABIN3022810)

Target: Cyclin T1 (CCNT1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin T1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cyclin T1 Antibody

Binding Specificity: AA 220-320

Sequence: HWWEYVDATV TLELLDELTH EFLQILEKTP NRLKRIWNWR ACEAAKKTKA DDRGTDEKTS EQTILNMISQ SSSDTTIAGL MSMSTSTTSA VPSLPVSEES S

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 220-320 of human Cyclin T1 (NP_001231.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cyclin T1

Target: Cyclin T1 (CCNT1)

Alternative Name: CCNT1

Background: This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.,CCNT1,CCNT,CYCT1,HIVE1,cyclin-T1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Cyclins,Immunology & Inflammation,CCNT1

Molecular Weight: 21 kDa/80 kDa

Gene ID: 904

UniProt: O60563