HNF4A antibody (AA 200-300)

Catalog No. ABIN3022870

This anti-HNF4A antibody is a Rabbit Polyclonal antibody detecting HNF4A in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for HNF4A antibody (AA 200-300) (ABIN3022870)

Target: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNF4A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HNF4A Antibody

Binding Specificity: AA 200-300

Sequence: EWAKYIPAFC ELPLDDQVAL LRAHAGEHLL LGATKRSMVF KDVLLLGNDY IVPRHCPELA EMSRVSIRIL DELVLPFQEL QIDDNEYAYL KAIIFFDPDA K

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human HNF4A (NP_000448.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-HNF4A antibody (ABIN3022870)

Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).

Target Details for HNF4A

Target: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Alternative Name: HNF4A

Background: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.,HNF4A,FRTS4,HNF4,HNF4a7,HNF4a8,HNF4a9,HNF4alpha,MODY,MODY1,NR2A1,NR2A21,TCF,TCF14,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Wnt/β-Catenin Signaling Pathway,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cytochromes,AMPK Signaling Pathway,Endocrine and metabolic diseases,Diabetes,Stem Cells,Cardiovascular,Blood,Coagulation,Lipids,HNF4A

Molecular Weight: 43-56 kDa

Gene ID: 3172

UniProt: P41235

Pathways: AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process