TBP antibody (AA 1-100)

Catalog No. ABIN3023175

The Rabbit Polyclonal anti-TBP antibody is suitable to detect TBP in samples from Human. It has been validated for WB.

Quick Overview for TBP antibody (AA 1-100) (ABIN3023175)

Target: TBP (TATA Box Binding Protein (TBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBP Antibody

Binding Specificity: AA 1-100

Sequence: MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQAVAAA AVQQSTSQQA TQGTSGQAPQ

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TBP (NP_001165556.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TBP

Target: TBP (TATA Box Binding Protein (TBP))

Alternative Name: TBP

Background: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.,TBP,GTF2D,GTF2D1,HDL4,SCA17,TFIID,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Neuroscience,Neurodegenerative Diseases,TBP

Molecular Weight: 35 kDa/37 kDa

Gene ID: 6908

UniProt: P20226

Pathways: WNT Signaling