DNMT1 antibody (pSer714)

Catalog No. ABIN3023526

The Rabbit Polyclonal anti-DNMT1 antibody has been validated for WB and IF. It is suitable to detect DNMT1 in samples from Human.

Quick Overview for DNMT1 antibody (pSer714) (ABIN3023526)

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DNMT1 Antibody

Binding Specificity: pSer714

Sequence: MPSPK

Cross-Reactivity: Human

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around S714 of human Phospho-DNMT1-pS714 (NP_001370.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DNMT1

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Alternative Name: DNMT1

Background: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.,ADCADN,AIM,CXXC9,DNMT,HSN1E,MCMT,m.HsaI,DNMT1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,DNA methylation,Protein phosphorylation,DNMT1

Molecular Weight: 144 kDa/183 kDa/184 kDa

Gene ID: 1786

UniProt: P26358

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection