UACA antibody

Catalog No. ABIN3024023

This Mouse Monoclonal antibody specifically detects UACA in WB, IF and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for UACA antibody (ABIN3024023)

Target: UACA (Uveal Autoantigen With Coiled Coil Domains And Ankyrin Repeats (UACA))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This UACA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: AE-5

Product Details anti-UACA Antibody

Purification: Protein G affinity chromatography

Immunogen: Nuclei of myeloid leukemia biopsy cells were used as the immunogen for the UACA antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal dilution of the UACA antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the UACA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for UACA

Target: UACA (Uveal Autoantigen With Coiled Coil Domains And Ankyrin Repeats (UACA))

Alternative Name: UACA

Background: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Pathways: Positive Regulation of Endopeptidase Activity