HTR7 antibody (Cytoplasmic Domain)

Catalog No. ABIN302499

The Rabbit Polyclonal anti-HTR7 antibody (ABIN302499) specifically detects HTR7 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for HTR7 antibody (Cytoplasmic Domain) (ABIN302499)

Target: HTR7 (5-Hydroxytryptamine (serotonin) Receptor 7 (Adenylate Cyclase-Coupled) (HTR7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTR7 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HTR7 Antibody

Binding Specificity: Cytoplasmic Domain

Specificity: This antibody detects 5-HT7 Receptor (HTR7) at 3rd cytoplasmic domain.

Purification: Immunoaffinity Chromatography

Immunogen: HTR7 antibody was raised against synthetic peptide from 3rd cytoplasmic domain of human HTR7 / 5-HT7.

Application Details

Application Notes: Immunohistochemistry on paraffin sections (10 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for HTR7

Target: HTR7 (5-Hydroxytryptamine (serotonin) Receptor 7 (Adenylate Cyclase-Coupled) (HTR7))

Alternative Name: Serotonin Receptor 7 (HTR7)

Background: 5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autistism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa, isoform b: 432aa, isoform d: 479aa.Synonyms: 5-HT-7, 5-hydroxytryptamine receptor 7, 5HT7

Gene ID: 3363

NCBI Accession: NP_000863

UniProt: P34969

Pathways: JAK-STAT Signaling