ADRA1B antibody (Cytoplasmic Domain)

Catalog No. ABIN302517

This anti-ADRA1B antibody is a Rabbit Polyclonal antibody detecting ADRA1B in IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for ADRA1B antibody (Cytoplasmic Domain) (ABIN302517)

Target: ADRA1B (Adrenergic, alpha-1B-, Receptor (ADRA1B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA1B antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-ADRA1B Antibody

Binding Specificity: Cytoplasmic Domain

Specificity: This antibody detects Alpha 1b-Adrenoceptor (ADRA1B) at 3rd cytoplasmic domain.

Purification: Immunoaffinity chromatography

Immunogen: ADRA1B antibody was raised against synthetic peptide from 3rd cytoplasmic domain of human ADRA1B.

Application Details

Application Notes: Immunohistochemistry on paraffin sections (10 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for ADRA1B

Target: ADRA1B (Adrenergic, alpha-1B-, Receptor (ADRA1B))

Alternative Name: alpha-1B Adrenergic Receptor

Background: The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation.Synonyms: ADRA1B, Alpha 1B-adrenoceptor, Alpha 1B-adrenoreceptor

Gene ID: 147

NCBI Accession: NP_000670

UniProt: P35368

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process