PDE1C antibody (C-Term)

Catalog No. ABIN302536

This Rabbit Polyclonal antibody specifically detects PDE1C in IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PDE1C antibody (C-Term) (ABIN302536)

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1C antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDE1C Antibody

Binding Specificity: C-Term

Specificity: This antibody detects Phosphodiesterase 1C (PDE1C) at C-terminal domain. Mouse and Rat.

Purification: Immunoaffinity chromatography

Immunogen: PDE1C antibody was raised against synthetic peptide from C-terminal domain of human PDE1C.

Application Details

Application Notes: Immunohistochemistry on paraffin sections (5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.21 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for PDE1C

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Alternative Name: PDE1C

Background: Phosphodiesterase 1C is a cAMP/cGMP dual-specific, calcium/calmodullin-dependent phosphodiesterase. PDE1C has been shown to affect vascular smooth muscle proliferation and atherosclerosis, insulin secretion regulation, spermatozoa development, and erectile dysfunction. At least five PDE1C isoforms have been reported, the expression of which are regulated in a tissue/cell-specific manner.Synonyms: 5'-cyclic nucleotide phosphodiesterase 1C, Calcium/calmodulin-dependent 3', Cam-PDE 1C, HCAM3, Phosphodiesterase 1C, Phosphodiesterase-1C calmodulin-dependent, hCam-3

Gene ID: 5137

NCBI Accession: NP_001177985

UniProt: Q14123

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma