MYB antibody (AA 119-135)

Catalog No. ABIN3026199

The Mouse Monoclonal anti-MYB antibody is suitable to detect MYB in samples from Human. It has been validated for ELISA.

Quick Overview for MYB antibody (AA 119-135) (ABIN3026199)

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYB antibody is un-conjugated

Application: ELISA

Clone: MYB286

Product Details anti-MYB Antibody

Binding Specificity: AA 119-135

Purpose: c-Myb Antibody

Sequence: RRKVEQEGYP QESSKAG

Purification: Protein G affinity chromatography

Immunogen: Amino acids 119-135 (RRKVEQEGYPQESSKAG) from the human protein were used as the immunogen for this c-Myb antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The optimal dilution of the c-Myb antibody for each application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the c-Myb antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MYB

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Alternative Name: c-Myb

Background: The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.

UniProt: P01104

Pathways: Chromatin Binding, Positive Regulation of Immune Effector Process