MYB antibody (AA 119-135)
Quick Overview for MYB antibody (AA 119-135) (ABIN3026200)
Target
See all MYB AntibodiesReactivity
Host
Clonality
Conjugate
Application
Grade
Clone
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Binding Specificity
- AA 119-135
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Purpose
- c-Myb Antibody (azide and preservative free)
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Sequence
- RRKVEQEGYP QESSKAG
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Purification
- Protein G affinity chromatography
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Immunogen
- Amino acids 119-135 (RRKVEQEGYPQESSKAG) from the human protein were used as the immunogen for this c-Myb antibody.
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Isotype
- IgG1, kappa
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Application Notes
- The optimal dilution of the c-Myb antibody for each application should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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Preservative
- Azide free
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store the c-Myb antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))
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Alternative Name
- c-Myb
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Background
- The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.
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UniProt
- P01104
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Pathways
- Chromatin Binding, Positive Regulation of Immune Effector Process
Target
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