IRAK3 antibody

Catalog No. ABIN302829

The Rabbit Polyclonal anti-IRAK3 antibody (ABIN302829) specifically detects IRAK3 in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for IRAK3 antibody (ABIN302829)

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IRAK3 Antibody

Specificity: This antibody reacts to a peptide corresponding to amino acids from the carboxy terminus of IRAK-M.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide

Application Details

Application Notes: Western Blot: 0,5 - 1 μg/mL. Immunohistochemistry: 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline, containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer.

Target Details for IRAK3

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Alternative Name: IRAK3

Background: IRAK-M, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK-M is immediately downstream of the MyD88 adapter protein and immediately upstream of TRAF6. At least three mRNA transcripts have been reported - an approximately 8-kb doublet and a 2.5-kb transcript that matched isolated cDNA. IRAK-M (-/-) mice have increased inflammatory responses to bacterial infection.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3

Gene ID: 11213

NCBI Accession: NP_001135995

UniProt: Q9Y616

Pathways: TLR Signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades